Identifying protein complex by integrating characteristic of core-attachment into dynamic PPI network
نویسندگان
چکیده
منابع مشابه
Identifying protein complex by integrating characteristic of core-attachment into dynamic PPI network
How to identify protein complex is an important and challenging task in proteomics. It would make great contribution to our knowledge of molecular mechanism in cell life activities. However, the inherent organization and dynamic characteristic of cell system have rarely been incorporated into the existing algorithms for detecting protein complexes because of the limitation of protein-protein in...
متن کاملPredicting Protein Complexes from PPI Data: A Core-Attachment Approach
UNLABELLED Protein complexes play a critical role in many biological processes. Identifying the component proteins in a protein complex is an important step in understanding the complex as well as the related biological activities. This paper addresses the problem of predicting protein complexes from the protein-protein interaction (PPI) network of one species using a computational approach. Mo...
متن کاملNeighbor Affinity-Based Core-Attachment Method to Detect Protein Complexes in Dynamic PPI Networks.
Protein complexes play significant roles in cellular processes. Identifying protein complexes from protein-protein interaction (PPI) networks is an effective strategy to understand biological processes and cellular functions. A number of methods have recently been proposed to detect protein complexes. However, most of methods predict protein complexes from static PPI networks, and usually overl...
متن کاملIdentifying protein complexes and functional modules - from static PPI networks to dynamic PPI networks
Cellular processes are typically carried out by protein complexes and functional modules. Identifying them plays an important role for our attempt to reveal principles of cellular organizations and functions. In this article, we review computational algorithms for identifying protein complexes and/or functional modules from protein-protein interaction (PPI) networks. We first describe issues an...
متن کاملIdentifying protein complexes and functionalmodulesçfrom static PPI networks to dynamic PPI networks
Cellular processes are typically carried out by protein complexes and functional modules. Identifying them plays an important role for our attempt to reveal principles of cellular organizations and functions. In this article, we review computational algorithms for identifying protein complexes and/or functional modules from protein^protein interaction (PPI) networks. We first describe issues an...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: PLOS ONE
سال: 2017
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0186134